Description

5-o-(Triphenylmethyl)-2-C-Methyl-D-Ribonic-γ-Lactone CAS NO 157666-05-2 is a high-purity, protected sugar derivative and a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile scaffold for constructing complex nucleoside analogs and other bioactive molecules with precise stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology industries, particularly those developing antiviral agents, nucleotide-based therapeutics, and fine chemical intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside and nucleotide analogs with potential antiviral or anticancer activity.
• Chiral Building Block: Used in asymmetric synthesis to introduce the 2-C-methyl-D-ribose moiety into complex target molecules, ensuring correct stereochemical configuration.
• Antiviral Drug Research: Serves as a core structure in the development of polymerase inhibitors for viruses such as Hepatitis C (HCV).
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing high-value, specialized organic compounds.
• Biochemical Research: Utilized in studying enzyme mechanisms and metabolic pathways involving modified sugars and nucleosides.
• Protecting Group Chemistry: The triphenylmethyl (trityl) group offers selective protection for hydroxyl groups during multi-step synthetic sequences.

Basic Information

Product Name	5-o-(Triphenylmethyl)-2-C-Methyl-D-Ribonic-γ-Lactone
CAS No.	157666-05-2
Molecular Formula	C26H26O5
Molecular Weight	418.48 g/mol
Synonyms	2-C-Methyl-D-ribono-1,4-lactone 5-O-trityl ether; 5-O-Trityl-2-C-methyl-D-ribono-1,4-lactone; 2-C-Methyl-5-O-trityl-D-ribono-γ-lactone; 5-O-(Triphenylmethyl)-2-C-methyl-D-ribono-γ-lactone; Tritylated 2-C-Methyl-D-ribonolactone; 2-C-Methyl-D-ribono-1,4-lactone 5-O-(triphenylmethyl) ether; 157666-05-2; 5-O-Trityl-2-C-methylribonolactone
EINECS	Contact for details

Quality Control

Our 5-o-(Triphenylmethyl)-2-C-Methyl-D-Ribonic-γ-Lactone is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.