Description

2-Pyrrolidinethione, 1-[[(Trimethylsilyl)oxy]methyl]- is a specialized organosilicon compound featuring a protected hydroxymethyl group and a thione functionality. This unique molecular architecture makes it a valuable building block and intermediate in advanced synthetic chemistry, particularly for the development of pharmaceuticals and agrochemicals. It is primarily utilized by research institutions and industrial R&D departments engaged in medicinal chemistry and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, especially those targeting neurological and metabolic disorders.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its reactive thione and silyl-protected groups.
• Ligand and Catalyst Development: Acts as a starting material for creating complex ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptidomimetic Research: The pyrrolidinethione core is valuable for constructing peptidomimetics and protease inhibitors in biochemical studies.
• Material Science Precursor: Employed in the synthesis of functionalized polymers and advanced materials with specific surface properties.
• Custom Synthesis & Contract Manufacturing: A critical intermediate for custom synthesis projects requiring precise chemical modifications.

Basic Information

Item	Details
Product Name	2-Pyrrolidinethione, 1-[[(Trimethylsilyl)oxy]methyl]-
CAS No.	157439-39-9
Molecular Formula	C8H17NOSSi
Molecular Weight	203.38 g/mol
Synonyms	1-[(Trimethylsilyloxy)methyl]-2-pyrrolidinethione; 1-(Hydroxymethyl)-2-pyrrolidinethione trimethylsilyl ether; 1-((Trimethylsilyloxy)methyl)-2-thioxopyrrolidine; 2-Thioxo-1-pyrrolidinemethanol trimethylsilyl ether; N-(Trimethylsilyloxymethyl)-2-pyrrolidinethione; TMS-protected 1-hydroxymethyl-2-pyrrolidinethione
EINECS	Contact for details

Quality Control

Every batch of 2-Pyrrolidinethione, 1-[[(Trimethylsilyl)oxy]methyl]- is produced and tested under a strict quality management system. We ensure high purity and batch-to-batch consistency through advanced analytical techniques including HPLC, GC, and NMR. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.