Description

tert-Butyl 3-acetyl-4-oxopiperidine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its piperidinone scaffold. This compound is of significant value for its role as a versatile building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, including potential candidates for central nervous system (CNS) and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting neurological and psychiatric conditions.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Used in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) with complex heterocyclic architectures.
• Chemical Biology Probes: Employed in the development of chemical probes for studying enzyme function and biological pathways.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Academic Research: Utilized in university and institutional labs for methodological development and the exploration of new synthetic routes.

Basic Information

Product Name	tert-Butyl 3-Acetyl-4-Oxopiperidine-1-Carboxylate
CAS No.	157327-43-0
Molecular Formula	C12H19NO4
Molecular Weight	241.28 g/mol
Synonyms	1-Boc-3-acetyl-4-piperidinone; 1-(tert-Butoxycarbonyl)-3-acetyl-4-piperidinone; 3-Acetyl-1-Boc-4-piperidinone; tert-Butyl 3-acetyl-4-oxo-1-piperidinecarboxylate; 4-Oxo-1-piperidinecarboxylic acid, 3-acetyl-, 1,1-dimethylethyl ester; 3-Acetyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester; 1-N-Boc-3-acetyl-4-piperidone
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-acetyl-4-oxopiperidine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports applications in GMP and non-GMP pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.