Description

Spirocyclohexane-1,2-1,3Dioxino4,5,6-Hiindolizin-9-Ol, 8-(1,1-Dimethylethyl)Dimethylsilyloxyoctahydro-, 3As-(3A.Alpha.,8.Alpha.,9.Beta.,9A.Beta.,9B.Alpha.)- is a complex, high-purity spirocyclic organic compound featuring a protected hydroxyl group, making it a valuable advanced pharmaceutical intermediate and a versatile building block in sophisticated organic synthesis. Its intricate molecular architecture is specifically designed for constructing complex bioactive molecules, offering researchers and manufacturers a critical tool for developing new active pharmaceutical ingredients (APIs). This compound is essential for R&D and production teams in the pharmaceutical, agrochemical, and fine chemical sectors seeking to create novel compounds with specific stereochemical configurations.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug candidates, particularly for central nervous system (CNS) and antiviral therapeutics.
• Agrochemical Research: Used in the development of novel, high-efficacy pesticides and herbicides with specific modes of action.
• Fine Chemical Synthesis: Serves as a precursor for creating specialty chemicals, catalysts, and ligands used in asymmetric synthesis.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, particularly in spirocycle and heterocycle formation.
• Material Science: Potential monomer or precursor for developing specialized polymers with unique thermal or optical properties.

Basic Information

Product Name	Spirocyclohexane-1,2-1,3Dioxino4,5,6-Hiindolizin-9-Ol, 8-(1,1-Dimethylethyl)Dimethylsilyloxyoctahydro-, 3As-(3A.Alpha.,8.Alpha.,9.Beta.,9A.Beta.,9B.Alpha.)-
CAS No.	156206-14-3
Molecular Formula	C22H37NO3Si
Molecular Weight	391.62 g/mol
Synonyms	8-(tert-Butyldimethylsilyloxy)octahydrospiro[cyclohexane-1,2'-[1,3]dioxino[4,5,6-hi]indolizin]-9-ol (3aR,8R,9S,9aR,9bS)-isomer; tert-Butyldimethyl((3aR,8R,9S,9aR,9bS)-9-hydroxyoctahydrospiro[cyclohexane-1,2'-[1,3]dioxino[4,5,6-hi]indolizin]-8-yloxy)silane; (3aR,8R,9S,9aR,9bS)-8-[(tert-Butyldimethylsilyl)oxy]octahydrospiro[cyclohexane-1,2'-[1,3]dioxino[4,5,6-hi]indolizin]-9-ol; TBDMS-protected spirocyclic indolizinol; Spirocyclic TBDMS ether intermediate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.