Description

Spirocyclohexane-1,2-1,3Dioxino4,5,6-Hiindolizin-8-Amine, Octahydro-9-(Methoxymethoxy)-n-(Phenylmethyl)-, 3As-(3A.Alpha.,8.Alpha.,9.Beta.,9A.Beta.,9B.Alpha.)- is a complex, high-purity spirocyclic amine derivative of significant interest in advanced organic synthesis. This compound matters as a sophisticated chiral building block and key intermediate for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce unique three-dimensional complexity into their target molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral scaffold in the research and synthesis of new drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Agrochemical Synthesis: Used as a building block for developing novel, high-performance pesticides and herbicides with specific stereochemical requirements.
• Ligand and Catalyst Development: Employed in the creation of novel chiral ligands for asymmetric catalysis and organocatalysts.
• Fine Chemical Production: Acts as a key intermediate in the multi-step synthesis of complex, high-value specialty chemicals and flavors/fragrances.
• Academic and Industrial Research: Utilized in methodological studies and the exploration of new spirocyclic compound libraries for biological screening.
• Material Science Precursor: Investigated for the synthesis of advanced organic materials with specific optical or electronic properties.

Basic Information

Item	Details
Product Name	Spirocyclohexane-1,2-1,3Dioxino4,5,6-Hiindolizin-8-Amine, Octahydro-9-(Methoxymethoxy)-n-(Phenylmethyl)-, 3As-(3A.Alpha.,8.Alpha.,9.Beta.,9A.Beta.,9B.Alpha.)-
CAS No.	156205-97-9
Molecular Formula	C23H32N2O4
Molecular Weight	400.52 g/mol
Synonyms	Octahydro-9-(methoxymethoxy)-N-(phenylmethyl)-spiro[cyclohexane-1,2'-[1,3]dioxino[4,5,6-hi]indolizin]-8-amine; (3aα,8α,9β,9aβ,9bα)-Octahydro-9-(methoxymethoxy)-N-(phenylmethyl)spiro[cyclohexane-1,2'-[1,3]dioxino[4,5,6-hi]indolizin]-8-amine; 156205-97-9; Spirocyclic amine derivative; Benzyl-protected spirocyclic amino acetal.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols. Each batch undergoes comprehensive analytical characterization using techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as chiral purity and chemical assay. We support development under cGMP guidelines where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.