Description

2-Cbz-Amino-4-Methylpent-2-Enoic Acid Methyl Ester is a protected amino acid derivative, specifically a Cbz-protected dehydroleucine methyl ester. This compound serves as a crucial chiral building block and versatile synthetic intermediate in advanced organic synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce constrained, unsaturated amino acid residues.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to create analogs with modified backbone properties.
• Protease Inhibitor Development: Serves as a core component in designing inhibitors that mimic transition states.
• Chemical Biology: Utilized for the synthesis of labeled or modified peptides for biochemical assays and probe development.
• Academic & Industrial R&D: A valuable reagent for methodologies development and exploring new synthetic routes in organic chemistry.

Basic Information

Product Name	2-Cbz-Amino-4-Methylpent-2-Enoic Acid Methyl Ester
CAS No.	156174-28-6
Molecular Formula	C15H19NO4
Molecular Weight	277.32 g/mol
Synonyms	Methyl (2Z)-2-[[(benzyloxy)carbonyl]amino]-4-methylpent-2-enoate; (Z)-Methyl 2-((((benzyloxy)carbonyl)amino)-4-methylpent-2-enoate; Cbz-dehydroleucine methyl ester; N-Carbobenzoxy-dehydroleucine methyl ester; N-Cbz-δLeu-OMe; (Z)-2-(((Benzyloxy)carbonyl)amino)-4-methylpent-2-enoic acid methyl ester; 2-[(Benzyloxycarbonyl)amino]-4-methyl-2-pentenoic acid methyl ester
EINECS	Contact for details

Quality Control

Our 2-Cbz-Amino-4-Methylpent-2-Enoic Acid Methyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.