Description

n-α-Fmoc-n-α-(2-Fmoc-Oxy-4-Methoxybenzyl)-Glycine Pentafluorophenyl Ester is a specialized, high-purity amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound matters because it serves as a key building block for introducing the acid-labile 4-methoxybenzyl (Mob) protected glycine residue into complex peptide chains, enabling the synthesis of challenging sequences. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and CROs/CDMOs engaged in the development of novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected amino acid active ester for the efficient, racemization-free incorporation of glycine with orthogonal side-chain protection.
• Peptide Drug Discovery: A critical reagent for constructing peptide libraries and novel peptide-based drug candidates in medicinal chemistry.
• Synthesis of Modified Peptides: Used to introduce glycine residues with the acid-labile 4-methoxybenzyl (Mob) protecting group, which is selectively removable under mild acidic conditions.
• Process Development for APIs: Employed in the scale-up and optimization of synthetic routes for peptide Active Pharmaceutical Ingredients (APIs).
• Bioconjugation and Labeling: Can serve as a precursor for creating custom linkers or labeled peptides for diagnostic and research applications.

Basic Information

Product Name	n-α-Fmoc-n-α-(2-Fmoc-Oxy-4-Methoxybenzyl)-Glycine Pentafluorophenyl Ester
CAS No.	156126-44-2
Molecular Formula	C45H34F5NO8
Molecular Weight	811.75 g/mol
Synonyms	Fmoc-Gly(2-Fmoc-O-4-MeOBzl)-OPfp; Fmoc-Gly(Mob-Fmoc)-OPfp ester; Nα-Fmoc-Nα-(2-Fmoc-oxy-4-methoxybenzyl)glycine pentafluorophenyl ester; Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]oxy]-4-methoxybenzyl]-, 2,3,4,5,6-pentafluorophenyl ester; Fmoc-Gly(Mob(Fmoc))-OPfp; Pentafluorophenyl N-Fmoc-N-(2-Fmocoxy-4-methoxybenzyl)glycinate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for peptide synthesis reagents. Every batch is characterized by HPLC, NMR, and mass spectrometry to confirm identity and high purity. Certificates of Analysis (COA) with detailed chromatographic data are available upon request. We adhere to a quality management system suitable for supplying materials for research and development under cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.