Description

(S)-Ethyl 2-Amino-4-Fluoro-4-Methylpentanoate CAS NO 156047-39-1 is a high-purity, non-natural amino acid ester derivative, specifically engineered as a critical chiral building block for advanced organic synthesis. Its value lies in the unique combination of a fluorine atom and a tertiary carbon center, which are essential for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is indispensable for research and development chemists in the pharmaceutical and agrochemical industries who are developing novel active ingredients, particularly protease inhibitors and other bioactive peptides.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially protease inhibitors (e.g., HIV protease inhibitors) and other peptide-based therapeutics.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides where the fluorine moiety enhances lipophilicity and environmental stability.
• Peptidomimetics: Serves as a crucial building block for creating peptidomimetic compounds that mimic natural peptides but with improved pharmacokinetic profiles.
• Chemical Biology Probes: Employed in the design and synthesis of labeled or tagged molecules for studying enzyme mechanisms and protein interactions.
• Asymmetric Synthesis: Utilized as a starting material or auxiliary in catalytic asymmetric reactions to introduce chiral centers into complex molecular architectures.
• Material Science: Potential precursor for specialty polymers and advanced materials requiring fluorinated amino acid components.

Basic Information

Product Name	(S)-Ethyl 2-Amino-4-Fluoro-4-Methylpentanoate
CAS No.	156047-39-1
Molecular Formula	C8H16FNO2
Molecular Weight	177.22 g/mol
Synonyms	(S)-Ethyl 2-Amino-4-fluoro-4-methylpentanoate; L-2-Amino-4-fluoro-4-methylpentanoic acid ethyl ester; Ethyl (2S)-2-amino-4-fluoro-4-methylpentanoate; 4-Fluoro-4-methyl-L-norvaline ethyl ester; (S)-2-Amino-4-fluoro-4-methylpentanoic acid ethyl ester; 156047-39-1; UNII-9F8T6C8Q2H; 9F8T6C8Q2H
EINECS	Contact for details

Quality Control

Our (S)-Ethyl 2-Amino-4-Fluoro-4-Methylpentanoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.