Description

Methyl (S)-4,4-Difluoropyrrolidine-2-Carboxylate Hydrochloride is a high-purity, chiral fluorinated pyrrolidine building block essential for modern pharmaceutical research and development. Its core value lies in its role as a key intermediate for synthesizing advanced drug candidates, particularly in the areas of protease inhibitors and other biologically active molecules. This compound is critically needed by medicinal chemists and process development scientists within pharmaceutical, biotechnology, and fine chemical industries to accelerate the discovery of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel drug candidates targeting various diseases.
• Protease Inhibitor Development: Used in the research and production of inhibitors for proteolytic enzymes like DPP-4, crucial for diabetes and other metabolic disorder treatments.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a building block in the multi-step synthesis of complex, fluorinated active pharmaceutical ingredients.
• Medicinal Chemistry & SAR Studies: Enables structure-activity relationship (SAR) exploration by introducing a rigid, fluorinated pyrrolidine scaffold into molecular frameworks.
• Peptidomimetic Research: Integral for creating peptidomimetics where the difluoropyrrolidine moiety mimics peptide turn structures to enhance metabolic stability and bioavailability.
• Bioconjugation & Probe Synthesis: Can be utilized for labeling and probe development in chemical biology due to its reactive ester group and unique fluorine atoms.

Basic Information

Item	Details
Product Name	Methyl (S)-4,4-Difluoropyrrolidine-2-Carboxylate Hydrochloride
CAS No.	156046-05-8
Molecular Formula	C7H10F2NO2·HCl
Molecular Weight	209.61 (Free base) / 246.07 (HCl salt)
Synonyms	(S)-Methyl 4,4-difluoropyrrolidine-2-carboxylate hydrochloride; Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate HCl; (2S)-4,4-Difluoropyrrolidine-2-carboxylic acid methyl ester hydrochloride; (S)-4,4-Difluoropyrrolidine-2-carboxylic acid methyl ester hydrochloride; L-4,4-Difluoropyrrolidine-2-carboxylic acid methyl ester hydrochloride; (S)-Methyl 4,4-difluoropyrrolidine-2-carboxylate monohydrochloride
EINECS	Contact for details

Quality Control

Our Methyl (S)-4,4-Difluoropyrrolidine-2-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.