Description

(R,S)-3-[(tert-Butyldimethylsilyl)Oxy]-2-Methyl-Butanoic Acid Methyl Ester is a valuable chiral synthon and protected hydroxy acid derivative, primarily used as a key intermediate in sophisticated organic synthesis. Its core value lies in the tert-butyldimethylsilyl (TBDMS) protecting group, which offers robust stability under a wide range of reaction conditions while allowing for selective deprotection. This compound is essential for researchers and process chemists in the pharmaceutical and fine chemical industries engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and complex natural products.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of chiral drug candidates, particularly those requiring stereocontrolled introduction of a branched alkyl chain with a protected alcohol functionality.
• Asymmetric Synthesis: Used in stereoselective transformations, including alkylations, aldol reactions, and reductions, to construct complex molecular architectures with high enantiomeric purity.
• Peptidomimetics & Pro-drug Development: Serves as a precursor for non-natural amino acids or as a pro-moiety to modify the pharmacokinetic properties of therapeutic agents.
• Agrochemical Synthesis: Employed in the research and production of advanced pesticides and herbicides where specific chirality impacts biological activity.
• Material Science Research: Acts as a monomer or functionalization agent in the development of specialized polymers with tailored properties.
• Academic & R&D Laboratories: A versatile reagent for methodological development in organic chemistry and for the total synthesis of complex natural products.

Basic Information

Product Name	(R,S)-3-[(tert-Butyldimethylsilyl)Oxy]-2-Methyl-Butanoic Acid Methyl Ester
CAS No.	155897-72-6
Molecular Formula	C₁₂H₂₆O₃Si
Molecular Weight	246.42 g/mol
Synonyms	Methyl 3-[(tert-Butyldimethylsilyl)oxy]-2-methylbutanoate; 2-Methyl-3-[(tert-butyldimethylsilyl)oxy]butyric Acid Methyl Ester; Methyl 2-Methyl-3-[(tert-butyldimethylsilyl)oxy]butanoate; 3-(tert-Butyldimethylsiloxy)-2-methylbutyric Acid Methyl Ester; TBDMS-protected 2-Methyl-3-hydroxybutyric Acid Methyl Ester; DL-3-[(tert-Butyldimethylsilyl)oxy]-2-methylbutanoic Acid Methyl Ester; (RS)-Methyl 3-((tert-butyldimethylsilyl)oxy)-2-methylbutanoate
EINECS	Contact for details

Quality Control

Our (R,S)-3-[(tert-Butyldimethylsilyl)Oxy]-2-Methyl-Butanoic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and chiral analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	Reported on COA
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.