Description

Benzyl 2-Bromo-2,2-Difluoroacetate is a specialized fluorinated building block of significant interest in advanced organic synthesis. This compound matters for its role in introducing the difluoromethyl moiety, a key structural feature that can dramatically alter the metabolic stability, lipophilicity, and bioavailability of target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key reagent for the synthesis of difluoromethyl-containing drug candidates, particularly in protease inhibitors and kinase modulators.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where the difluoromethyl group enhances biological activity.
• Material Science Research: Serves as a monomer or precursor for developing fluorinated polymers with unique surface properties and chemical resistance.
• Organic Synthesis Building Block: Employed in nucleophilic substitution and cross-coupling reactions to construct complex, fluorinated molecular architectures.
• Ligand and Catalyst Development: Useful for preparing fluorinated ligands for metal complexes used in catalysis.
• Fluorine Chemistry Research: A valuable tool for academic and industrial labs studying the synthesis and reactivity of gem-difluorinated compounds.

Basic Information

Product Name	Benzyl 2-Bromo-2,2-Difluoroacetate
CAS No.	155820-63-6
Molecular Formula	C9H7BrF2O2
Molecular Weight	265.05 g/mol
Synonyms	2-Bromo-2,2-difluoroacetic Acid Benzyl Ester; Benzyl Bromodifluoroacetate; Bromodifluoroacetic Acid Benzyl Ester; α-Bromo-α,α-difluoroacetic Acid Phenylmethyl Ester; (Benzyloxy)carbonyl Bromodifluoromethane; Benzyl α-Bromo-α,α-difluoroacetate
EINECS	Contact for details

Quality Control

Our Benzyl 2-Bromo-2,2-Difluoroacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.