Description

4-Methyl Ethynyl Estradiol is a synthetic steroidal estrogen derivative, distinguished by its methyl and ethynyl modifications. This compound is of significant interest in pharmaceutical research and development due to its potent and selective estrogenic activity profile. It serves as a critical intermediate or active pharmaceutical ingredient (API) for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced life sciences sectors, particularly those focused on endocrinology, hormone therapy, and novel therapeutic agent synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced steroidal drugs and hormone-based therapies.
• Biomedical Research: Used as a reference standard or experimental compound in studies investigating estrogen receptor (ER) signaling pathways and mechanisms.
• Endocrinology Studies: Employed in preclinical research to model and understand the effects of modified estrogens on biological systems.
• API Development: Serves as a precursor or the core structure in the development of new Active Pharmaceutical Ingredients (APIs) with targeted estrogenic activity.
• Chemical Synthesis: A valuable synthon for organic and medicinal chemists creating novel steroid analogs with potential therapeutic applications.

Basic Information

Item	Details
Product Name	4-Methyl Ethynyl Estradiol
CAS No.	155683-61-7
Molecular Formula	C21H26O2
Molecular Weight	310.43 g/mol
Synonyms	4-Methyl-17α-ethynylestradiol; 17α-Ethynyl-4-methylestra-1,3,5(10)-triene-3,17β-diol; 4-Methyl-19-nor-17α-pregna-1,3,5(10)-trien-20-yne-3,17β-diol; 4-Methyl EE2; 4-Methyl Ethynylestradiol; 4-ME-EE2; 4-Methyl-17α-ethynyl-estra-1,3,5(10)-triene-3,17β-diol
EINECS	Contact for details

Quality Control

Our 4-Methyl Ethynyl Estradiol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets stringent specifications for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.