Description

Plerixafor 8Hcl (Amd3100 8Hcl) CAS NO 155148-31-5 is a high-purity, small molecule CXCR4 chemokine receptor antagonist used as a critical pharmaceutical active ingredient. Its primary value lies in its ability to mobilize hematopoietic stem cells from the bone marrow into the bloodstream, a vital step in stem cell transplantation procedures. This compound is essential for pharmaceutical manufacturers, clinical research organizations, and biotechnology companies developing and producing therapies for oncology and immunology.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of stem cell mobilizing agents for autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma.
• Clinical Research: Used as a key reagent in preclinical and clinical studies investigating CXCR4 receptor biology, cancer metastasis, and HIV entry inhibition.
• Biotechnology & Cell Therapy: Employed in ex vivo stem cell mobilization protocols for advanced cell and gene therapy manufacturing.
• Oncology Research: A vital tool for studying tumor microenvironment, cancer stem cells, and developing novel anti-metastatic therapies.
• Immunology Research: Used to investigate leukocyte trafficking, inflammatory responses, and autoimmune disease mechanisms.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.

Basic Information

Product Name	Plerixafor 8Hcl (Amd3100 8Hcl)
CAS No.	155148-31-5
Molecular Formula	C28H54N8•8HCl
Molecular Weight	792.70 g/mol (as free base: 502.79 g/mol)
Synonyms	AMD3100 Octahydrochloride; 1,1'-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane] octahydrochloride; JM 3100; Mozobil (brand name salt form); Plerixafor Hydrochloride; Cyclam Octahydrochloride; CXCR4 Antagonist; Stem Cell Mobilizer
EINECS	Contact for details

Quality Control

Our Plerixafor 8HCl is manufactured under strict quality management systems. Each batch is tested to ensure it meets stringent specifications for pharmaceutical intermediates and research applications. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, supporting compliance with cGMP and ICH guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.