Description

4'-Dehydroxy-4'-Fluoroamodiaquine is a key fluorinated derivative and synthetic intermediate of the antimalarial drug amodiaquine. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, drug discovery, and the development of new antimalarial compounds.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel amodiaquine analogs and antimalarial candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to investigate the impact of fluorination on drug efficacy and metabolism.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Active Pharmaceutical Ingredient (API) Development: Employed in the R&D of new chemical entities (NCEs) targeting parasitic diseases.
• Biochemical Research: Utilized in studies exploring drug-target interactions and resistance mechanisms in malaria parasites.
• Process Chemistry: Acts as a key intermediate in the scale-up and optimization of synthetic routes for complex drug molecules.

Basic Information

Product Name	4'-Dehydroxy-4'-Fluoroamodiaquine
CAS No.	155020-42-1
Molecular Formula	C20H22ClF2N3O
Molecular Weight	393.86 g/mol
Synonyms	4'-Dehydroxy-4'-fluoroamodiaquine; 4'-Fluoroamodiaquine Impurity; 2-[(7-Chloro-4-quinolinyl)amino]-5-[(diethylamino)methyl]-4-fluorophenol; 4'-F-Amodiaquine; Amodiaquine 4'-Fluoro Impurity; 4'-Fluoro Amodiaquine; 4'-F-AQ; 4'-Dehydroxy-4'-fluoro Amodiaquine Dihydrochloride Salt (common salt form)
EINECS	Contact for details

Quality Control

Our 4'-Dehydroxy-4'-Fluoroamodiaquine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for pharmaceutical intermediates, and custom synthesis to meet specific purity requirements (e.g., >95%, >98%, >99%) is available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong alkalis and fluorinating agents. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.