Description

2-((tert-Butyldiphenylsilyl)Oxy)-n-Methoxy-n-Methylacetamide is a specialized organosilicon-protected intermediate of significant value in advanced organic synthesis. This compound matters for its role as a key building block in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing sensitive molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for protecting sensitive functional groups during complex reactions.
• Peptide Synthesis: Used in the preparation of modified amino acid derivatives and peptide fragments where selective protection is required.
• Agrochemical Research: Serves as a precursor in the development of novel herbicides, fungicides, and insecticides that require sophisticated silicon-based protecting group strategies.
• Material Science: Employed in the synthesis of specialty polymers and advanced organic materials that incorporate silicon-oxygen functionalities.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry, enabling new synthetic pathways and protecting group methodologies.
• Process Chemistry: Used in scale-up and optimization studies for the commercial production of high-value fine chemicals.

Basic Information

Product Name	2-((tert-Butyldiphenylsilyl)Oxy)-n-Methoxy-n-Methylacetamide
CAS No.	154698-93-8
Molecular Formula	C20H27NO3Si
Molecular Weight	357.52 g/mol
Synonyms	N-Methoxy-N-methyl-2-[(2-methyl-2-phenyl-1-sila-1-propyl)oxy]acetamide; 2-[(tert-Butyldiphenylsilyl)oxy]-N-methoxy-N-methylacetamide; Acetamide, 2-[(1,1-dimethylethyl)diphenylsilyl]oxy]-N-methoxy-N-methyl-; TBDPS-protected Weinreb amide derivative; N-Methoxy-N-methyl-2-(tert-butyldiphenylsilyloxy)acetamide; 2-(tert-Butyldiphenylsiloxy)-N-methoxy-N-methylacetamide; Silicon-protected Weinreb amide
EINECS	Contact for details

Quality Control

Our 2-((tert-Butyldiphenylsilyl)Oxy)-n-Methoxy-n-Methylacetamide is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality commitment aligns with the standards expected in pharmaceutical R&D and fine chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as fluorides and strong alkalis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.