Description

Methyl 2-((tert-Butyldiphenylsilyl)Oxy)Acetate CAS NO 154698-92-7 is a high-purity, protected glycolic acid derivative, serving as a versatile and critical building block in advanced organic synthesis. Its primary value lies in its role as a robust protecting group for alcohols and carboxylic acids, enabling complex multi-step reactions with high selectivity and yield. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries, particularly for the development of active pharmaceutical ingredients (APIs) and complex natural products.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules, especially those requiring selective protection/deprotection strategies.
• Peptide Synthesis: Used to protect side-chain hydroxyl groups of amino acids like serine and threonine during solid-phase and solution-phase peptide synthesis.
• Natural Product Synthesis: Facilitates the construction of sensitive glycosidic linkages and polyol segments found in macrolides, sugars, and other natural compounds.
• Agrochemical Research: Intermediate in the development of novel herbicides, fungicides, and plant growth regulators with specific stereochemical requirements.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialized polymers and advanced materials.
• Academic & R&D Laboratories: A standard reagent for methodological development in organic chemistry, particularly in studies involving silyl ether chemistry.

Basic Information

Product Name	Methyl 2-((tert-Butyldiphenylsilyl)Oxy)Acetate
CAS No.	154698-92-7
Molecular Formula	C19H24O3Si
Molecular Weight	328.48 g/mol
Synonyms	Methyl (tert-Butyldiphenylsilyloxy)acetate; Acetic acid, 2-[(1,1-dimethylethyl)diphenylsilyl]oxy]-, methyl ester; Methyl (TBDPSO)acetate; 2-[(tert-Butyldiphenylsilyl)oxy]acetic acid methyl ester; Methyl O-(tert-Butyldiphenylsilyl)glycolate; TBDPS-protected methyl glycolate; Methyl glycolate TBDPS ether
EINECS	Contact for details

Quality Control

Our Methyl 2-((tert-Butyldiphenylsilyl)Oxy)Acetate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding R&D and scale-up processes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and our quality protocols are designed to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is sensitive to fluoride ions and strong alkali; ensure it is stored separately from such materials to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.