Description

3-(tert-Butyldimethylsilyloxy)Piperidine is a high-purity, protected piperidine derivative that serves as a critical chiral building block and intermediate in advanced organic synthesis. This compound is valued for its role in introducing the piperidine moiety while offering protection for the hydroxyl group via a robust tert-butyldimethylsilyl (TBDMS) ether, enabling complex multi-step reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs), novel drug candidates, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of central nervous system (CNS) drugs, analgesics, and other therapeutic agents containing the piperidine scaffold.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the piperidine structure confers specific biological activity.
• Asymmetric Catalysis: Employed as a ligand precursor or a chiral auxiliary in catalytic asymmetric synthesis to induce enantioselectivity.
• Peptidomimetics & Molecular Probes: Integral for constructing peptide analogs and biochemical probes used in medicinal chemistry and biological research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.
• Academic & Industrial R&D: A valuable reagent for method development and exploring new synthetic pathways in university and corporate research laboratories.

Basic Information

Product Name	3-(tert-Butyldimethylsilyloxy)Piperidine
CAS No.	154544-53-3
Molecular Formula	C11H25NOSi
Molecular Weight	215.41 g/mol
Synonyms	3-[(1,1-Dimethylethyl)dimethylsilyl]oxy]piperidine; 3-(Tert-Butyldimethylsiloxy)piperidine; 3-(TBDMS-Oxy)piperidine; 3-[(tert-Butyldimethylsilyl)oxy]piperidine; 3-Hydroxypiperidine TBDMS ether; 3-OTBDMS-piperidine; Piperidin-3-ol, 1-(1,1-dimethylethyl)dimethylsilyl ether; 3-(tert-Butyldimethylsilyloxy)piperidine
EINECS	Contact for details

Quality Control

Our 3-(tert-Butyldimethylsilyloxy)Piperidine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive synthetic applications. We employ advanced analytical techniques including GC, HPLC, and NMR to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) are provided with each shipment, detailing all relevant specifications. Our quality management system supports compliance with cGMP and ISO standards for research and development materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Specific Rotation [α]	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.