Description

4-Ethynyl-Benzeneacetic Acid Methyl Ester is a versatile aromatic acetylene derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both an ethynyl group and a methyl ester, makes it a valuable precursor for constructing complex molecular architectures through cross-coupling and cycloaddition reactions. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides requiring specific aromatic-acetylene frameworks.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and conductive materials.
• Ligand and Catalyst Preparation: Utilized for synthesizing sophisticated ligands for metal-organic catalysis and asymmetric synthesis.
• Chemical Biology Probes: Acts as a click chemistry handle (via the alkyne group) for bioconjugation and labeling applications.
• Academic & R&D: Fundamental research compound in organic chemistry for methodology development and heterocycle synthesis.

Basic Information

Product Name	4-Ethynyl-Benzeneacetic Acid Methyl Ester
CAS No.	154498-13-2
Molecular Formula	C11H10O2
Molecular Weight	174.20 g/mol
Synonyms	Methyl 4-Ethynylphenylacetate; 4-Ethynylbenzeneacetic Acid Methyl Ester; Methyl (4-Ethynylphenyl)acetate; p-Ethynylphenylacetic Acid Methyl Ester; (4-Ethynylphenyl)acetic Acid Methyl Ester; 4-Ethynyl-α-toluic Acid Methyl Ester; Methyl 2-(4-Ethynylphenyl)acetate; Benzeneacetic acid, 4-ethynyl-, methyl ester
EINECS	Contact for details

Quality Control

Our 4-Ethynyl-Benzeneacetic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.