Description

(1-Benzyl-4-Nitromethyl-Piperidin-4-Yl)-Acetic Acid Ethyl Ester is a specialized piperidine derivative organic intermediate of significant interest in advanced chemical synthesis. This compound matters for its role as a key building block in the development of complex pharmacologically active molecules, offering a versatile nitromethyl and ester functional handle for further chemical transformations. It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents, particularly within medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, especially those targeting the central nervous system (CNS).
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Organic Synthesis Building Block: The nitromethyl and ester groups provide reactive sites for various transformations, including reductions, alkylations, and cyclizations.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and advanced materials.
• Academic & Industrial R&D: A valuable reagent for developing new synthetic methodologies and exploring novel chemical spaces in academic and corporate laboratories.

Basic Information

Product Name	(1-Benzyl-4-Nitromethyl-Piperidin-4-Yl)-Acetic Acid Ethyl Ester
CAS No.	154495-66-6
Molecular Formula	C18H26N2O4
Molecular Weight	334.41 g/mol
Synonyms	Ethyl (1-benzyl-4-nitromethylpiperidin-4-yl)acetate; 4-(Ethoxycarbonylmethyl)-1-benzyl-4-nitromethylpiperidine; 1-Benzyl-4-(nitromethyl)-4-(2-ethoxy-2-oxoethyl)piperidine; 4-(2-Ethoxy-2-oxoethyl)-1-benzyl-4-(nitromethyl)piperidine; (1-Benzyl-4-nitromethylpiperidin-4-yl)acetic acid ethyl ester; 154495-66-6; 1-Benzyl-4-nitromethyl-4-piperidineacetic acid ethyl ester
EINECS	Contact for details

Quality Control

Our (1-Benzyl-4-Nitromethyl-Piperidin-4-Yl)-Acetic Acid Ethyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing specific test results is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	Light yellow to yellow solid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical: 97-99%)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.