Description

Carbamic Acid, [1-(Chloromethyl)-2-Propenyl]-, 1,1-Dimethylethyl Ester, (R)- is a chiral, protected amino acid derivative of significant value in advanced organic synthesis. This compound matters as a key chiral building block, enabling the stereoselective construction of complex molecules with high enantiomeric purity. Pharmaceutical and agrochemical research and development teams need it for the synthesis of active pharmaceutical ingredients (APIs), peptide mimetics, and other biologically active compounds where the (R)-configuration is critical.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of novel APIs, particularly in oncology, neurology, and antiviral therapies.
• Peptidomimetic Synthesis: Used to incorporate non-natural, functionalized amino acid units into peptide chains to enhance stability, bioavailability, and biological activity.
• Agrochemical Active Ingredient Development: Serves as a building block for creating enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Preparation: Employed in the synthesis of chiral ligands for asymmetric catalysis and organocatalysts.
• Custom Chemical Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for bespoke, multi-step synthetic routes for clients.
• Academic and Industrial Research: A valuable reagent for methodological development in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Item	Detail
Product Name	Carbamic Acid, [1-(Chloromethyl)-2-Propenyl]-, 1,1-Dimethylethyl Ester, (R)-
CAS No.	154264-66-1
Molecular Formula	C10H18ClNO2
Molecular Weight	219.71 g/mol
Synonyms	(R)-N-(tert-Butoxycarbonyl)-3-chloro-2-methylenepropylamine; (R)-N-Boc-3-chloro-2-methylenepropylamine; (R)-tert-Butyl (1-(chloromethyl)prop-2-en-1-yl)carbamate; (R)-1-(Chloromethyl)-2-propenylcarbamic Acid tert-Butyl Ester; (R)-Boc-3-chloro-2-methylenepropylamine; (R)-N-Boc-3-chloro-2-methylenepropan-1-amine; tert-Butyl N-[(1R)-1-(chloromethyl)prop-2-en-1-yl]carbamate
EINECS	Contact for details

Quality Control

Our production of Carbamic Acid, [1-(Chloromethyl)-2-Propenyl]-, 1,1-Dimethylethyl Ester, (R)- adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including chiral HPLC to confirm enantiomeric excess (ee) and identity/purity verification via NMR, IR, and GC/HPLC. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.