Description

n-Acetyl-L-Alanine N-Hydroxysuccinimide Ester is a high-purity, activated ester derivative of N-acetyl-L-alanine, designed for efficient peptide synthesis and bioconjugation. This compound is a critical reagent for introducing the N-acetyl-alanine moiety into target molecules under mild conditions, enabling the creation of stable amide bonds. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and the production of custom peptides and antibody-drug conjugates (ADCs), where precise and reliable coupling is paramount.

Application

• Peptide Synthesis: As an activated building block for the solid-phase or solution-phase incorporation of N-acetyl-alanine.
• Bioconjugation & ADC Development: For coupling payloads, linkers, or reporter molecules to proteins, antibodies, or other biomolecules.
• Proteomics Research: Used in chemical labeling strategies for mass spectrometry-based protein analysis and identification.
• Cross-linking Agent: In the preparation of affinity matrices, immobilized enzymes, or other cross-linked biopolymers.
• Organic Synthesis Intermediate: Serves as a key intermediate for synthesizing more complex organic molecules and pharmaceutical ingredients.
• Biomaterial Functionalization: For modifying surfaces or polymers with bioactive peptide sequences.

Basic Information

Product Name	n-Acetyl-L-Alanine N-Hydroxysuccinimide Ester
CAS No.	154194-69-1
Molecular Formula	C11H14N2O6
Molecular Weight	270.24 g/mol
Synonyms	N-Acetyl-L-alanine N-hydroxysuccinimide ester; N-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-N-acetyl-L-alanine; N-Acetylalanine NHS ester; Ac-Ala-OSu; N-Acetylalanine N-hydroxysuccinimide ester; N-Acetyl-L-alanine succinimidyl ester; N-Hydroxysuccinimide ester of N-acetyl-L-alanine; N-Succinimidyl N-acetyl-L-alaninate
EINECS	Contact for details

Quality Control

Our n-Acetyl-L-Alanine N-Hydroxysuccinimide Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and cGMP manufacturing. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.