Description

6-[(2R,6S)-2,6-Dimethylmorpholin-4-Yl]Pyridin-3-Amine Dihydrochloride is a high-purity, chiral organic salt primarily used as a critical pharmaceutical intermediate. Its value lies in its role as a key building block for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical control. This compound is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of novel drug candidates, particularly for central nervous system (CNS) and antiviral targets.
• API Development: Used in the development and scale-up of Active Pharmaceutical Ingredients (APIs) that incorporate the 2,6-dimethylmorpholine and aminopyridine pharmacophores.
• Process Chemistry: Serves as a standardized starting material or intermediate in process optimization and route scouting for new chemical entities (NCEs).
• Chemical Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Medicinal Chemistry Research: Utilized in structure-activity relationship (SAR) studies and library synthesis for drug discovery programs.
• Asymmetric Synthesis: Leveraged as a chiral auxiliary or precursor in stereoselective synthesis due to its defined (2R,6S) configuration.

Basic Information

Product Name	6-[(2R,6S)-2,6-Dimethylmorpholin-4-Yl]Pyridin-3-Amine Dihydrochloride
CAS No.	154179-39-2
Molecular Formula	C11H19N3O • 2HCl
Molecular Weight	294.21 g/mol (as free base: 209.29 g/mol)
Synonyms	(2R,6S)-4-(5-Amino-2-pyridinyl)-2,6-dimethylmorpholine dihydrochloride; 3-Pyridinamine, 6-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-, dihydrochloride; 6-((2R,6S)-2,6-Dimethylmorpholino)pyridin-3-amine dihydrochloride; (R,S)-cis-4-(5-Amino-2-pyridyl)-2,6-dimethylmorpholine dihydrochloride; 154179-39-2; UNII-4J2Z5K2A0P
EINECS	Contact for details

Quality Control

Our 6-[(2R,6S)-2,6-Dimethylmorpholin-4-Yl]Pyridin-3-Amine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Chiral Purity (Chiral HPLC)	≥99.0% (2R,6S) isomer
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single unknown impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.