Description

D-Valine, n-[(1,1-Dimethylethoxy)Carbonyl]-3-Methyl-, Methyl Ester is a protected amino acid derivative of significant importance in advanced organic synthesis. This compound serves as a crucial chiral building block for the construction of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including protease inhibitors and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for drugs targeting specific enzymatic pathways.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate the D-valine residue with orthogonal protecting groups (Boc) for complex sequence assembly.
• Protease Inhibitor Development: Serves as a core structural component in the design and synthesis of potent inhibitors for various proteases.
• Biochemical Research: Employed in studies of enzyme-substrate interactions, chiral recognition, and the structure-activity relationships (SAR) of peptide-based compounds.
• Material Science: Potential use in the synthesis of specialized polymers and materials where chiral amino acid motifs are required for specific properties.

Basic Information

Product Name	D-Valine, n-[(1,1-Dimethylethoxy)Carbonyl]-3-Methyl-, Methyl Ester
CAS No.	153960-35-1
Molecular Formula	C12H23NO4
Molecular Weight	245.32 g/mol
Synonyms	Boc-D-Valine methyl ester; (R)-2-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acid methyl ester; Methyl N-Boc-D-valinate; N-(tert-Butoxycarbonyl)-D-valine methyl ester; D-Valine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester; Methyl (R)-2-((tert-butoxycarbonyl)amino)-3-methylbutanoate; Boc-D-Val-OMe; N-Boc-D-valine methyl ester
EINECS	Contact for details

Quality Control

Our D-Valine, n-[(1,1-Dimethylethoxy)Carbonyl]-3-Methyl-, Methyl Ester is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.