Description

Fmoc-(S)-4-Amino-5-Hydroxybutanoic Acid T-Butyl Ester is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical building block for the introduction of the (S)-4-amino-5-hydroxybutanoic acid moiety under Fmoc solid-phase peptide synthesis (SPPS) conditions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and bioactive compounds. The tert-butyl ester protection ensures orthogonal deprotection strategies, offering chemists precise control over complex molecular assembly.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of modified amino acid structures into peptide chains using Fmoc chemistry protocols.
• Pharmaceutical Research & Development: Used in the discovery and synthesis of peptide-based drug candidates targeting various disease pathways.
• Peptidomimetic Design: Serves as a scaffold for creating non-natural peptide analogs with enhanced stability, bioavailability, or receptor affinity.
• Bioconjugation: Facilitates the site-specific modification of peptides or proteins for diagnostic or therapeutic applications.
• Chemical Biology Probes: Enables the synthesis of labeled or tagged peptides used to study protein-protein interactions and enzymatic activity.
• Academic Research: Employed in university and institutional labs for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	Fmoc-(S)-4-Amino-5-Hydroxybutanoic Acid T-Butyl Ester
CAS No.	153815-59-9
Molecular Formula	C24H29NO6
Molecular Weight	427.49 g/mol
Synonyms	Fmoc-Aad(5-OH)-OtBu; Fmoc-L-4-Amino-5-hydroxybutanoic acid tert-butyl ester; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-hydroxy-4-oxopentanoic acid tert-butyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-amino-5-hydroxybutanoic acid 1,1-dimethylethyl ester; Fmoc-4-NH2-5-OH-Bu-OtBu; tert-Butyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-hydroxy-4-oxopentanoate; Fmoc-4-Amino-5-hydroxybutyric acid t-butyl ester; Nα-Fmoc-4-amino-5-hydroxybutanoic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-4-Amino-5-Hydroxybutanoic Acid T-Butyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and chiral analysis to confirm enantiomeric integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light may lead to decomposition. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (S-enantiomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.