Description

Benzene, 4-Fluoro-1-Isocyano-2-Methyl- (9Ci) is a specialized aromatic building block featuring both a reactive isocyano group and a fluorine substituent on the benzene ring. This unique bifunctional structure makes it a valuable intermediate for synthesizing complex molecules in advanced research and development. It is primarily sought after by pharmaceutical and agrochemical R&D teams for constructing novel heterocyclic compounds and fluorinated active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly in medicinal chemistry programs targeting new therapeutic agents.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, where the fluorine atom can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a building block for creating specialized isocyanide-based ligands used in organometallic chemistry and catalysis.
• Material Science Research: Employed in the preparation of functionalized polymers and advanced organic materials with tailored properties.
• Chemical Biology Probes: Utilized for the synthesis of activity-based probes and other tools for studying biological systems.

Basic Information

Product Name	Benzene, 4-Fluoro-1-Isocyano-2-Methyl- (9Ci)
CAS No.	153797-68-3
Molecular Formula	C8H6FN
Molecular Weight	135.14 g/mol
Synonyms	2-Methyl-4-fluorophenyl isocyanide; 4-Fluoro-2-methylphenyl isocyanide; 1-Isocyano-4-fluoro-2-methylbenzene; 4-Fluoro-2-methylbenzenisocyanide; 2-Methyl-4-fluorobenzene isonitrile; 4-Fluoro-o-tolyl isocyanide; (4-Fluoro-2-methylphenyl)isocyanide
EINECS	Contact for details

Quality Control

Our Benzene, 4-Fluoro-1-Isocyano-2-Methyl- (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing all relevant specifications. We adhere to cGMP principles where applicable to support our clients in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is 2-8°C. Allow the container to reach ambient temperature before opening to minimize moisture ingress. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.