Description

tert-Butyl-L-n-Benzyloxycarbonylazetidine-2-Carboxylate is a high-purity, non-natural amino acid derivative featuring a protected azetidine ring, a key structural motif in advanced pharmaceutical synthesis. This compound serves as a critical chiral building block for the development of novel active pharmaceutical ingredients (APIs) and complex organic molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in peptide mimetics, protease inhibitors, and other sophisticated medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly protease inhibitors and enzyme modulators.
• Peptide Mimetics Development: Used to incorporate the constrained azetidine scaffold into peptide backbones to enhance metabolic stability and bioavailability.
• Medicinal Chemistry Research: Serves as a versatile building block in structure-activity relationship (SAR) studies and lead optimization.
• Asymmetric Synthesis: Employed in the preparation of complex, enantiomerically pure molecules due to its defined stereochemistry.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	tert-Butyl-L-n-Benzyloxycarbonylazetidine-2-Carboxylate
CAS No.	153704-88-2
Molecular Formula	C19H27NO4
Molecular Weight	333.43 g/mol
Synonyms	1-tert-Butyl 2-methyl (2S)-1-[(benzyloxy)carbonyl]azetidine-2-carboxylate; (2S)-1-[(Benzyloxy)carbonyl]azetidine-2-carboxylic acid tert-butyl ester; Boc-Azetidine(1-Cbz)-OH; L-1-Cbz-azetidine-2-carboxylic acid tert-butyl ester; tert-Butyl (2S)-1-{[(benzyloxy)carbonyl]amino}azetidine-2-carboxylate; Azetidine-2-carboxylic acid derivative; Cbz-Aze(tBu)-OH
EINECS	Contact for details

Quality Control

Our tert-Butyl-L-n-Benzyloxycarbonylazetidine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.