Description

Sp-8-Br-Cgmps is a high-purity, specialized biochemical reagent used as a potent and selective activator of soluble guanylyl cyclase (sGC). This compound is critical for advanced research in cellular signaling pathways, particularly those involving cyclic GMP (cGMP). It serves as an essential tool for pharmaceutical R&D, academic research, and biotechnology applications focused on cardiovascular, neurological, and metabolic disorders. The product is supplied under strict quality control to ensure reliable and reproducible experimental results.

Application

• Pharmaceutical Research & Development: A key tool compound for studying and validating sGC as a therapeutic target for pulmonary arterial hypertension (PAH), heart failure, and other cardiovascular diseases.
• Academic & Biomedical Research: Used in cell-based assays and animal studies to elucidate the role of the nitric oxide (NO)-sGC-cGMP signaling pathway in vascular tone, platelet aggregation, and neuronal function.
• Biochemical Assay Development: Employed as a reference standard and positive control in high-throughput screening (HTS) campaigns to discover novel sGC modulators.
• Signal Transduction Studies: Facilitates research into smooth muscle relaxation, vasodilation, and other physiological processes mediated by cGMP.
• Preclinical Drug Candidate Profiling: Used to compare the efficacy and potency of new chemical entities against a known, potent sGC activator.

Basic Information

Product Name	Sp-8-Br-Cgmps
CAS No.	153660-03-8
Molecular Formula	C10H12BrN5O7P2
Molecular Weight	488.09 g/mol
Synonyms	8-Bromoguanosine 3',5'-cyclic monophosphorothioate, Sp-isomer; Sp-8-Bromo-cGMPS; Sp-8-Br-cGMPS; 8-Bromo-Sp-cGMPS; (Sp)-8-Bromoguanosine-3',5'-cyclic monophosphorothioate; sGC Activator; B0770 (APExBIO); B1687 (Sigma).
EINECS	Contact for details

Quality Control

Every batch of Sp-8-Br-Cgmps is manufactured and analyzed under a strict quality management system. Our products undergo rigorous identity, purity, and potency testing using advanced analytical techniques including HPLC, NMR, and MS to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and analytical methods is provided with each shipment to guarantee traceability and reproducibility for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.