Description

3-Chloro-5-Ethoxypyridine-4-Carbonitrile is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its unique pyridine core, substituted with chloro, ethoxy, and nitrile groups, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its heterocyclic structure for bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating novel ligands in coordination chemistry and catalysts for asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as components for organic light-emitting diodes (OLEDs) or conductive polymers.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	3-Chloro-5-Ethoxypyridine-4-Carbonitrile
CAS No.	153463-57-1
Molecular Formula	C8H7ClN2O
Molecular Weight	182.61 g/mol
Synonyms	4-Cyano-3-chloro-5-ethoxypyridine; 5-Ethoxy-3-chloropyridine-4-carbonitrile; 3-Chloro-5-ethoxypyridine-4-carbonitrile; 3-Chloro-5-ethoxy-4-pyridinecarbonitrile; 4-Pyridinecarbonitrile, 3-chloro-5-ethoxy-; 153463-57-1; 3-Chloro-5-ethoxyisonicotinonitrile
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-5-Ethoxypyridine-4-Carbonitrile is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.