Description

4-o-Butanoyl-4'-Demethylpodophyllotoxin is a semi-synthetic derivative of podophyllotoxin, a naturally occurring lignan with significant biological activity. This compound serves as a crucial intermediate in the synthesis of more complex chemotherapeutic agents and is valued for its role in pharmaceutical research and development. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on oncology drug discovery and advanced organic synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel anti-cancer agents and other bioactive molecules.
• Oncology Research: Used in biochemical and pharmacological studies to investigate mechanisms of cell cycle inhibition, particularly as a topoisomerase II inhibitor.
• Medicinal Chemistry: Serves as a scaffold for structural modification to develop new derivatives with improved efficacy and reduced toxicity profiles.
• Reference Standard: Employed as an analytical standard in quality control laboratories for the identification and quantification of related compounds.
• Academic Research: Utilized in university and institutional labs for studies in natural product chemistry, organic synthesis, and drug design.

Basic Information

Product Name	4-o-Butanoyl-4'-Demethylpodophyllotoxin
CAS No.	153448-17-0
Molecular Formula	C28H30O9
Molecular Weight	510.54 g/mol
Synonyms	4-Butanoyl-4'-demethylpodophyllotoxin; 4-O-Butyryl-4'-demethylpodophyllotoxin; 4'-Demethyl-4-butanoylpodophyllotoxin; Podophyllotoxin, 4'-demethyl-4-butanoyl-; 4-Butanoyl-4'-desmethylpodophyllotoxin; 4'-Desmethyl-4-butanoylpodophyllotoxin; 4-O-Butanoyl-4'-demethylepipodophyllotoxin (related isomer); GP-11 (research code)
EINECS	Contact for details

Quality Control

Our 4-o-Butanoyl-4'-Demethylpodophyllotoxin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or manufacturing specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.