Description

5-(2,5-Dioxopyrrolidin-1-Yl)Pentanoic Acid is a high-purity chemical intermediate featuring a reactive N-hydroxysuccinimide (NHS) ester group. This compound is critical for facilitating efficient and stable amide bond formation, particularly in aqueous or mild conditions, making it a cornerstone reagent for bioconjugation. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics sectors who require reliable, high-quality building blocks for developing novel therapeutics, targeted drug delivery systems, and advanced diagnostic assays.

Application

• Bioconjugation Reagent: Primary use for covalently linking amines on proteins, peptides, antibodies, or other biomolecules to carboxylic acid-containing compounds.
• Pharmaceutical Intermediate: Key building block in the synthesis of antibody-drug conjugates (ADCs), peptide-drug conjugates, and other targeted therapeutic agents.
• Diagnostic Probe Synthesis: Used to attach fluorescent dyes, enzymes (e.g., HRP), or other reporter molecules to antibodies and proteins for ELISA, flow cytometry, and immunohistochemistry.
• Polymer and Material Science: Functionalization of polymers, nanoparticles, and surfaces with bioactive ligands for creating smart biomaterials and drug delivery platforms.
• Crosslinking Agent: Employed to create stable crosslinks between molecules in hydrogel formation or immobilization chemistry.
• Research & Development: A versatile tool in academic and industrial R&D for exploring new bioconjugation strategies and developing novel bioanalytical methods.

Basic Information

Product Name	5-(2,5-Dioxopyrrolidin-1-Yl)Pentanoic Acid
CAS No.	153195-41-6
Molecular Formula	C9H13NO5
Molecular Weight	215.20 g/mol
Synonyms	5-(N-Succinimidyloxycarbonyl)pentanoic Acid; 5-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-5-oxopentanoic Acid; NHS-Pentanoic Acid; 6-((2,5-Dioxopyrrolidin-1-yl)oxy)-6-oxohexanoic Acid; Glutaric Acid NHS Ester; N-Hydroxysuccinimide Glutarate; Succinimidyl Glutarate; 1-[(5-Carboxypentanoyl)oxy]-2,5-pyrrolidinedione
EINECS	Contact for details

Quality Control

Our 5-(2,5-Dioxopyrrolidin-1-Yl)Pentanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for bioconjugation and pharmaceutical synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.