Description

4H-1,3-Dioxolo4,5-Cpyrrole, 4-(1,1-Dimethylethyl)Dimethylsilyloxymethyl-3A,6A-Dihydro-2,2-Dimethyl-, (3Ar,4R,6As)- is a sophisticated chiral building block featuring a fused dioxolopyrrole core protected by a tert-butyldimethylsilyl (TBDMS) ether group. This compound is of significant value in asymmetric synthesis and pharmaceutical intermediate manufacturing, where its defined stereochemistry and protective group enable precise molecular construction. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological or metabolic pathways.
• Asymmetric Catalysis Research: Used as a ligand precursor or a stereodefined scaffold in the development of new catalytic systems.
• Agrochemical Synthesis: Serves as a building block for creating enantiomerically pure herbicides, fungicides, or plant growth regulators.
• Material Science: Potential monomer or precursor for chiral polymers and advanced organic electronic materials.
• Academic & Institutional R&D: Employed in methodological studies and the total synthesis of natural products.
• Process Chemistry Development: Used for scaling up synthetic routes under Current Good Manufacturing Practice (cGMP) conditions for clinical trial material production.

Basic Information

Product Name	4H-1,3-Dioxolo4,5-Cpyrrole, 4-(1,1-Dimethylethyl)Dimethylsilyloxymethyl-3A,6A-Dihydro-2,2-Dimethyl-, (3Ar,4R,6As)-
CAS No.	153172-33-9
Molecular Formula	C15H27NO3Si
Molecular Weight	297.47 g/mol
Synonyms	(3aR,4R,6aS)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxymethyl]-2,2-dimethyl-3a,6a-dihydro-4H-[1,3]dioxolo[4,5-c]pyrrole; 4-[(tert-Butyldimethylsilyloxy)methyl]-2,2-dimethyl-3a,6a-dihydro-4H-[1,3]dioxolo[4,5-c]pyrrole (3aR,4R,6aS)-; TBDMS-protected dioxolopyrrole derivative; Chiral dioxolopyrrole-TBDMS ether; (3aR,4R,6aS)-4-((tert-Butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrole
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and purity for sensitive synthetic applications. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm enantiomeric excess. A detailed Certificate of Analysis (COA) documenting identity, purity, and specific impurities is provided with each shipment. We support development under cGMP guidelines for pharmaceutical customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.