Description

4H-1,3-Dioxolo4,5-Cpyrrole, 4-(1,1-Dimethylethyl)Dimethylsilyloxymethyltetrahydro-2,2-Dimethyl-, (3Ar,4R,6As)- is a high-value, organosilicon-protected pyrrole derivative with significant utility in advanced organic synthesis. This compound is a critical chiral building block for pharmaceutical research and development, offering a protected functional handle for constructing complex molecular architectures. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and complex natural products.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Asymmetric Synthesis: Utilized as a building block in stereoselective reactions to introduce complex pyrrole-based motifs with defined stereochemistry.
• Natural Product Synthesis: Employed in the total synthesis of complex alkaloids and other natural products containing functionalized pyrrole rings.
• Agrochemical Research: Acts as an intermediate in the development of new pesticides and herbicides with novel modes of action.
• Material Science Precursor: Investigated for use in creating specialized organic semiconductors or ligands for catalytic systems.
• Process Chemistry: Used in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs).

Basic Information

Item	Detail
Product Name	4H-1,3-Dioxolo4,5-Cpyrrole, 4-(1,1-Dimethylethyl)Dimethylsilyloxymethyltetrahydro-2,2-Dimethyl-, (3Ar,4R,6As)-
CAS No.	153172-31-7
Molecular Formula	C15H29NO3Si
Molecular Weight	299.48 g/mol
Synonyms	(3aR,4R,6aS)-4-[[(tert-Butyldimethylsilyl)oxy]methyl]tetrahydro-2,2-dimethyl-4H-[1,3]dioxolo[4,5-c]pyrrole; 4-((tert-Butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrole; TBDMS-protected pyrrolidine acetonide; tert-Butyldimethyl((2,2-dimethyl-4,4a,5,6-tetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrol-4-yl)methoxy)silane; Chiral pyrrole dioxolane silyl ether; Pyrrolidine, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]tetrahydro-2,2-dimethyl-, (3aR,4R,6aS)-rel-; 153172-31-7
EINECS	Contact for details

Quality Control

Every batch of our 4H-1,3-Dioxolo4,5-Cpyrrole derivative is produced and tested under strict quality management protocols to ensure high purity, consistent chirality, and reliable performance in sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as chiral purity (enantiomeric excess), chemical purity (by HPLC/GC), and identity confirmation (by NMR, IR). Our quality systems are designed to support cGMP requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (argon or nitrogen) for long-term storage to prevent decomposition. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.