Description

2-Chloro-3-Fluoropyridine-4-Boronic Acid is a high-value, multi-functional boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex heterocyclic scaffolds. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those containing complex pyridine derivatives.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those for OLEDs and semiconductors, where the pyridine-boronic acid motif is valuable.
• Chemical Biology Probes: Useful for constructing molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke chemical synthesis projects requiring specific halogenated pyridine boronic acids.

Basic Information

Item	Details
Product Name	2-Chloro-3-Fluoropyridine-4-Boronic Acid
CAS No.	153122-60-2
Molecular Formula	C5H4BClFNO2
Molecular Weight	174.35 g/mol
Synonyms	(2-Chloro-3-fluoropyridin-4-yl)boronic acid; 2-Chloro-3-fluoro-4-pyridineboronic acid; 4-Borono-2-chloro-3-fluoropyridine; 2-Chloro-3-fluoropyridine-4-boronic acid pinacol ester (common derivative); 153122-60-2; 2-Chloro-3-fluoro-4-pyridinylboronic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-3-Fluoropyridine-4-Boronic Acid is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Assay (NMR/Titration)	≥95.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.