Description

Ethyl 4-(tert-Butyldimethylsilyloxy)Benzoate is a high-value, protected benzoate derivative featuring a tert-butyldimethylsilyl (TBDMS) ether group. This compound is a critical synthetic intermediate, prized for its role in protecting phenolic hydroxyl groups during complex multi-step organic syntheses. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the production of active pharmaceutical ingredients (APIs), fine chemicals, and functional organic molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules, particularly those requiring selective protection/deprotection strategies.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where phenolic protection is necessary.
• Advanced Material Precursor: Serves as a monomer or intermediate in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Organic Synthesis Reagent: Essential for academic and industrial research in constructing complex natural products and heterocyclic compounds.
• Chemical Biology Probe Development: Utilized in the synthesis of tagged molecules for studying biological pathways and mechanisms.

Basic Information

Product Name	Ethyl 4-(tert-Butyldimethylsilyloxy)Benzoate
CAS No.	153025-65-1
Molecular Formula	C15H24O3Si
Molecular Weight	280.44 g/mol
Synonyms	Ethyl 4-[(tert-Butyldimethylsilyl)oxy]benzoate; Benzoic acid, 4-[(1,1-dimethylethyl)dimethylsilyl]oxy]-, ethyl ester; 4-(tert-Butyldimethylsiloxy)benzoic acid ethyl ester; Ethyl p-(TBDMS-oxy)benzoate; 4-TBDMS-O-Benzoyl ethyl ester; Ethyl 4-(TBDMSO)benzoate; 153025-65-1; Ethyl 4-OTBDMS-benzoate
EINECS	Contact for details

Quality Control

Our Ethyl 4-(tert-Butyldimethylsilyloxy)Benzoate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Custom synthesis and purification to meet specific research or cGMP starting material guidelines are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Typical 98-99%)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.