Description

Progesterone 6-Hemimaleate is a high-purity, chemically modified derivative of progesterone, a key steroid hormone. This compound is specifically engineered to enhance stability and solubility for advanced pharmaceutical research and development. It serves as a critical intermediate or reference standard for scientists in the pharmaceutical, biotechnology, and academic sectors developing novel hormone-based therapies and diagnostic assays.

Application

• Pharmaceutical Intermediate: Used in the synthesis of novel progesterone analogs and prodrugs with targeted therapeutic profiles.
• Reference Standard: Serves as a high-purity calibrant in analytical methods (HPLC, LC-MS) for quality control and regulatory compliance in API manufacturing.
• Biochemical Research: A vital tool for studying progesterone receptor (PR) binding affinity, metabolism, and structure-activity relationships (SAR).
• Prodrug Development: The hemimaleate moiety can be utilized to improve the physicochemical properties, such as bioavailability, of parent steroid molecules.
• Veterinary Pharmaceuticals: Potential application in the development of reproductive health treatments for animals.

Basic Information

Product Name	Progesterone 6-Hemimaleate
CAS No.	152881-19-1
Molecular Formula	C24H30O5
Molecular Weight	398.50 g/mol
Synonyms	6-Hemimaleate of Progesterone; Progesterone 6-(Hydrogen Maleate); Pregn-4-ene-3,20-dione, 17-[(1-oxo-3-carboxy-2-propen-1-yl)oxy]-, (17α)-; Progesterone Maleate Ester; 17α-(1-Carboxyvinyloxy)pregn-4-ene-3,20-dione
EINECS	Contact for details

Quality Control

Our Progesterone 6-Hemimaleate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with detailed results to ensure traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is kept sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.