Description

(6S)-5-Azaspiro[2.4]Heptane-6-Carboxylic Acid CAS NO 152723-57-4 is a high-value, non-natural amino acid derivative featuring a unique spirocyclic structure. This compound serves as a critical chiral building block and intermediate in advanced pharmaceutical synthesis, enabling the development of novel therapeutic agents. It is primarily required by research institutions and pharmaceutical companies engaged in the discovery and production of complex small-molecule drugs, particularly those targeting the central nervous system.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) with complex molecular architectures.
• Drug Discovery Research: Used in medicinal chemistry for constructing novel compound libraries and probing structure-activity relationships (SAR).
• Peptidomimetics Development: The constrained spirocyclic structure makes it valuable for creating peptide analogs with enhanced metabolic stability and bioavailability.
• Ligand Synthesis for Catalysis: Potential use in the preparation of chiral ligands for asymmetric synthesis.
• Chemical Biology Probes: Employed in the design of molecular tools to study biological processes and enzyme function.

Basic Information

Product Name	(6S)-5-Azaspiro[2.4]Heptane-6-Carboxylic Acid
CAS No.	152723-57-4
Molecular Formula	C7H11NO2
Molecular Weight	141.17 g/mol
Synonyms	(6S)-5-Azaspiro[2.4]heptane-6-carboxylic acid; (S)-5-Azaspiro[2.4]heptane-6-carboxylic acid; (S)-6-Carboxy-5-azaspiro[2.4]heptane; 5-Azaspiro[2.4]heptane-6-carboxylic acid, (6S)-; (6S)-5-Azaspiro[2.4]heptane-6-carboxylic acid; (S)-Azetidine-2-spiro-1-cyclopropane-2-carboxylic acid; (S)-1-Azaspiro[2.3]hexane-2-carboxylic acid (alternative numbering).
EINECS	Contact for details

Quality Control

Our (6S)-5-Azaspiro[2.4]Heptane-6-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and chiral purity, meeting the exacting standards required for pharmaceutical R&D and scale-up. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and residual solvent content is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.