Description

1,1'-Bis(4-Sulfobutyl)-11-(4-Isothiocyanatophenylthio)-3,3,3',3'-Tetramethyl-10,12-Tri Methyleneindotricarbocyanine Monosodium Salt is a highly functionalized, near-infrared (NIR) fluorescent cyanine dye derivative. Its core value lies in its isothiocyanate (NCS) reactive group, which enables stable covalent conjugation to biomolecules like antibodies, proteins, and peptides for advanced diagnostic and research applications. This product is essential for manufacturers and researchers in the life sciences, in-vitro diagnostics (IVD), and biomedical imaging sectors who require high-performance labeling reagents.

Application

• Fluorescent Labeling of Biomolecules: Covalent conjugation to antibodies, proteins, and peptides for use in immunoassays (e.g., ELISA, Western Blot) and flow cytometry.
• In-Vitro Diagnostic (IVD) Reagent Kits: A key component in the development of fluorescent-based diagnostic tests and kits.
• Bioimaging and Biosensing: Used as a near-infrared (NIR) probe for in vitro and in vivo imaging applications due to its deep tissue penetration and low background fluorescence.
• Pharmaceutical Research: Employed in drug discovery for target identification, cellular tracking, and high-content screening assays.
• Molecular Biology: Labeling of nucleic acids or other probes for fluorescence in situ hybridization (FISH) and related techniques.
• Material Science: Potential use in the development of functionalized nanomaterials and sensors.

Basic Information

Product Name	1,1'-Bis(4-Sulfobutyl)-11-(4-Isothiocyanatophenylthio)-3,3,3',3'-Tetramethyl-10,12-Tri Methyleneindotricarbocyanine Monosodium Salt
CAS No.	152111-91-6
Molecular Formula	C52H58N3NaO6S4
Molecular Weight	~1000.3 g/mol
Synonyms	IR-783 Isothiocyanate; Cy7.5 Isothiocyanate; Sulfo-Cy7.5 NHS Ester analogue (isothiocyanate form); NIR-783 NCS; 1,1'-Bis(4-sulfobutyl)indotricarbocyanine-5-isothiocyanate; Heptamethine cyanine dye isothiocyanate; Monosodium 1,1'-bis(4-sulfobutyl)-11-(4-isothiocyanatophenylthio)-3,3,3',3'-tetramethyl-10,12-trimethyleneindotricarbocyanine
EINECS	Contact for details

Quality Control

Our 1,1'-Bis(4-Sulfobutyl)-11-(4-Isothiocyanatophenylthio)-3,3,3',3'-Tetramethyl-10,12-Tri Methyleneindotricarbocyanine Monosodium Salt is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent performance, and batch-to-batch reproducibility critical for sensitive bio-conjugation applications. Certificates of Analysis (COA) detailing purity, identity, and functional performance are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Dark green to blue-black solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 5.0 %
Functional Performance	Conjugation efficiency confirmed

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.