Description

(S)-(+)-n-Desmethyl Zopiclone is a high-purity chiral intermediate and a key metabolite of the sedative-hypnotic agent zopiclone. This compound is essential for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions, analytical laboratories, and pharmaceutical companies engaged in the development of central nervous system (CNS) therapeutics and generic drug formulations.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantitative and qualitative analysis of zopiclone and its metabolites in biological matrices.
• Metabolite Research: Critical for in-vitro and in-vivo studies investigating the metabolic pathways, bioavailability, and clearance mechanisms of zopiclone.
• Chiral Synthesis Building Block: Used as a high-value intermediate in the asymmetric synthesis of novel sedative-hypnotic compounds and for impurity profiling.
• Analytical Method Development: Employed for calibrating equipment and validating analytical methods (e.g., HPLC, LC-MS) in quality control and forensic laboratories.
• Pharmacology Studies: Facilitates research into the structure-activity relationships (SAR) and receptor binding affinities of non-benzodiazepine hypnotics.

Basic Information

Product Name	(S)-(+)-n-Desmethyl Zopiclone
CAS No.	151776-26-0
Molecular Formula	C16H15ClN6O2
Molecular Weight	358.78 g/mol
Synonyms	(S)-(+)-Desmethylzopiclone; (S)-Zopiclone N-Desmethyl Metabolite; (6S)-6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-Methylpiperazine-1-carboxylate; (S)-N-Desmethyl Zopiclone; (S)-(+)-Zopiclone Impurity F; (S)-Zopiclone Metabolite; ES-Zopiclone Metabolite
EINECS	Contact for details

Quality Control

Our (S)-(+)-n-Desmethyl Zopiclone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and impurities is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.