Description

5-Methoxydehydropodophyllotoxin is a high-purity, semi-synthetic derivative of podophyllotoxin, a naturally occurring lignan with significant biological activity. This compound serves as a critical advanced pharmaceutical intermediate for the synthesis of novel chemotherapeutic agents and other bioactive molecules. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in developing next-generation anti-cancer drugs and exploring new therapeutic applications.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel podophyllotoxin-derived anti-cancer agents and other therapeutic compounds.
• Biomedical Research: Used as a reference standard and active agent in biochemical and pharmacological studies targeting tubulin polymerization and cell cycle inhibition.
• Organic Synthesis: Valuable building block for medicinal chemists to create libraries of compounds for high-throughput screening and structure-activity relationship (SAR) studies.
• Academic Research: Employed in university and institutional labs for investigating the mechanisms of cytotoxic natural products and their derivatives.

Basic Information

Product Name	5-Methoxydehydropodophyllotoxin
CAS No.	151703-06-9
Molecular Formula	C23H22O8
Molecular Weight	426.42 g/mol
Synonyms	5-Methoxydehydropodophyllotoxin; 5-Methoxy-4'-demethyldehydropodophyllotoxin; 5-Methoxy-4'-demethylpodophyllotoxin quinone; 5-Methoxy-4'-demethylpodophyllotoxin-7'-one; NSC 348948; 5-Methoxy-4'-desmethyldehydropodophyllotoxin; 5-Methoxy-4'-desmethylpodophyllotoxin quinone
EINECS	Contact for details

Quality Control

Our 5-Methoxydehydropodophyllotoxin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data to support your research and development needs. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product should be kept under an inert atmosphere if long-term stability is required.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.