Description

Phenethyldiisopropylchlorosilane is a specialized organosilicon reagent featuring a reactive chlorosilane group and a phenethyl moiety. This compound is a critical intermediate for introducing silyl protecting groups in complex organic synthesis, offering enhanced steric bulk and stability. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the protection of alcohols and other sensitive functional groups.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the selective protection of hydroxyl groups in the multi-step synthesis of active pharmaceutical ingredients (APIs) and complex natural products.
• Agrochemical Manufacturing: Used in the production of advanced pesticides and herbicides where robust protecting groups are required for specific synthetic pathways.
• Peptide and Oligonucleotide Chemistry: Employed to protect sensitive functional groups during solid-phase and solution-phase synthesis, preventing unwanted side reactions.
• Material Science Research: Serves as a precursor or surface modifying agent in the development of specialty silicones, silsesquioxanes, and other hybrid organic-inorganic materials.
• Cross-Coupling Catalysis: Can be used to prepare specialized ligands or silylating agents for transition metal-catalyzed reactions.
• Analytical Derivatization: Utilized to silylate compounds for Gas Chromatography (GC) or Mass Spectrometry (MS) analysis to improve volatility and detection.

Basic Information

Product Name	Phenethyldiisopropylchlorosilane
CAS No.	151613-24-0
Molecular Formula	C14H23ClSi
Molecular Weight	254.87 g/mol
Synonyms	Chloro(phenethyl)diisopropylsilane; Diisopropyl(phenethyl)chlorosilane; Phenethylchlorodiisopropylsilane; 2-Phenylethylchlorodiisopropylsilane; (2-Phenylethyl)diisopropylchlorosilane; Chloro(2-phenylethyl)diisopropylsilane; Silane, chlorodiisopropyl(2-phenylethyl)-
EINECS	Contact for details

Quality Control

Our Phenethyldiisopropylchlorosilane is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management standards to guarantee product integrity from synthesis to packaging.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts vigorously with strong acids and water; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.