Description

Levomefolate Calcium is the biologically active, calcium salt form of the 5-methyltetrahydrofolate (5-MTHF) isomer, a critical cofactor in one-carbon metabolism. This high-purity ingredient is essential for formulating advanced nutraceutical and pharmaceutical products targeting folate deficiency and supporting methylation processes. It is primarily utilized by manufacturers in the dietary supplement, clinical nutrition, and pharmaceutical industries seeking a direct, bioavailable source of folate that bypasses the metabolic conversion required by folic acid.

Application

• Dietary Supplements: A key bioactive ingredient in prenatal vitamins, multivitamins, and standalone folate supplements designed for superior bioavailability.
• Pharmaceutical Formulations: Used in prescription and over-the-counter medications for managing hyperhomocysteinemia and specific metabolic disorders.
• Clinical & Medical Nutrition: Incorporated into medical foods and enteral formulas for patients with specific nutritional needs or malabsorption issues.
• Functional Food & Beverage Fortification: An advanced option for fortifying foods and drinks where a stable, bioactive folate is required.
• Research & Development: Serves as a high-purity reference standard and raw material in biochemical and clinical research studies.

Basic Information

Product Name	Levomefolate Calcium
CAS No.	151533-22-1
Molecular Formula	C20H23CaN7O6
Molecular Weight	497.53 g/mol
Synonyms	(6S)-5-Methyltetrahydrofolate Calcium Salt; L-Methylfolate Calcium; Metafolin® (Brand Name); (6S)-5-MTHF Calcium; 5-Methyl-(6S)-tetrahydrofolic acid, calcium salt; Levofolinic Acid Calcium Salt; (6S)-5-Methyl-5,6,7,8-tetrahydrofolic acid calcium salt
EINECS	Contact for details

Quality Control

Our Levomefolate Calcium is manufactured under strict quality systems. Each batch is tested to ensure it meets high-purity standards suitable for nutraceutical and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) is provided, detailing parameters such as assay, enantiomeric purity, and impurity profiles. We support compliance with relevant guidelines including cGMP for active pharmaceutical ingredients (APIs).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 97.0% (on anhydrous basis)
Enantiomeric Purity (HPLC)	≥ 98.0% (6S)-isomer
Water Content (KF)	≤ 8.0%
Residue on Ignition	≤ 1.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.