Description

4-Chloro-3-Pyrrolidin-1-Yl-Benzoic Acid Methyl Ester is a high-value, synthetically versatile chemical intermediate. This compound is critical for research and development in advanced organic synthesis, particularly in constructing complex molecular architectures. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs) and other specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders.
• Agrochemical Research: Used in the development of novel herbicides and pesticides, leveraging its heterocyclic and aromatic structure.
• Material Science: Serves as a precursor for advanced polymers and liquid crystals due to its rigid benzoic acid ester core and functionalizable pyrrolidine group.
• Organic Synthesis: Employed in cross-coupling reactions, amidation, and hydrolysis to create a diverse library of 3,4-disubstituted benzoic acid derivatives.
• Chemical Biology: Useful as a molecular scaffold or probe in medicinal chemistry for structure-activity relationship (SAR) studies.

Basic Information

Product Name	4-Chloro-3-Pyrrolidin-1-Yl-Benzoic Acid Methyl Ester
CAS No.	151296-58-1
Molecular Formula	C₁₄H₁₆ClNO₂
Molecular Weight	265.74 g/mol
Synonyms	Methyl 4-chloro-3-(pyrrolidin-1-yl)benzoate; Benzoic acid, 4-chloro-3-(1-pyrrolidinyl)-, methyl ester; 4-Chloro-3-(1-pyrrolidinyl)benzoic acid methyl ester; Methyl 4-chloro-3-pyrrolidin-1-ylbenzoate; 151296-58-1; 4-Chloro-3-pyrrolidin-1-yl-benzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-3-Pyrrolidin-1-Yl-Benzoic Acid Methyl Ester adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We operate under a quality system designed to meet the rigorous standards required for pharmaceutical and advanced chemical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.