Description

2-Butyl-1,3-Diazaspiro[4.4]Non-1-En-4-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a complex spirocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily sought by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially those targeting central nervous system (CNS) disorders.
• Drug Discovery & Development: Used in medicinal chemistry research for constructing spirocyclic scaffolds to explore new biological activities and improve drug-like properties.
• Chemical Synthesis Building Block: Employed in organic synthesis for constructing complex heterocyclic compounds due to its reactive diazaspiro core.
• Process Chemistry: Serves as a standardized intermediate in the scale-up and optimization of API manufacturing processes under GMP conditions.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs engaged in custom synthesis projects for pharmaceutical clients.

Basic Information

Product Name	2-Butyl-1,3-Diazaspiro[4.4]Non-1-En-4-One Hydrochloride
CAS No.	151257-01-1
Molecular Formula	C12H21N2O·HCl
Molecular Weight	236.77 g/mol (Free base: 200.31 g/mol)
Synonyms	2-Butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride; 1,3-Diazaspiro[4.4]non-1-en-4-one, 2-butyl-, hydrochloride; 2-Butyl-1,3-diazaspiro[4.4]non-1-en-4-one HCl; Spirocyclic butyl diazaenone hydrochloride; 151257-01-1; UNII-9B8F8C8W2C; 9B8F8C8W2C
EINECS	Contact for details

Quality Control

Our 2-Butyl-1,3-Diazaspiro[4.4]Non-1-En-4-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. A Certificate of Analysis (COA) documenting all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.