Description

2H-Pyran-2-One,4-Fluorotetrahydro-3,5,6-Trimethyl-,[3R-(3Alpha,4Beta,5Alpha,6Alpha)]-(9Ci) is a high-purity, stereochemically defined fluorinated lactone building block. This compound is valued for its precise molecular architecture, which is critical for introducing specific stereocenters and fluorine atoms into complex target molecules. It serves as a key chiral intermediate for research and development in advanced pharmaceutical synthesis, particularly for active pharmaceutical ingredients (APIs) and agrochemicals requiring fluorinated motifs.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and production of fluorinated drug candidates, including potential antivirals, CNS agents, and anti-inflammatory compounds.
• Agrochemical Synthesis: Used in the development of novel, high-performance pesticides and herbicides where the fluorine atom enhances biological activity and metabolic stability.
• Advanced Material Research: Serves as a specialized monomer or precursor for synthesizing fluorinated polymers and specialty chemicals with unique properties.
• Asymmetric Catalysis & Method Development: Employed as a test substrate or ligand precursor in academic and industrial research focused on new fluorination and stereoselective synthesis methodologies.
• Fine Chemical Production: Integral to the multi-step synthesis of complex, high-value fluorinated fine chemicals for various industrial applications.

Basic Information

Product Name	2H-Pyran-2-One,4-Fluorotetrahydro-3,5,6-Trimethyl-,[3R-(3Alpha,4Beta,5Alpha,6Alpha)]-(9Ci)
CAS No.	150418-20-5
Molecular Formula	C8H11FO2
Molecular Weight	158.17 g/mol
Synonyms	(3R,4R,5S,6R)-4-Fluoro-3,5,6-trimethyltetrahydro-2H-pyran-2-one; 4-Fluoro-3,5,6-trimethyltetrahydro-2H-pyran-2-one (stereoisomer); Fluorinated Tetramethyl Dihydro-2H-pyran-2-one; 150418-20-5; (3α,4β,5α,6α)-4-Fluorotetrahydro-3,5,6-trimethyl-2H-pyran-2-one; Fluorinated Lactone Intermediate; Stereospecific Fluoropyranone
EINECS	Contact for details

Quality Control

Every batch of this fluorinated lactone intermediate is produced under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) that detail purity, stereochemical integrity, and impurity profiles, typically determined by advanced analytical techniques including chiral HPLC, GC, NMR, and MS. Our quality commitment ensures the material meets the exacting standards required for pharmaceutical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.