Description

7-(5-(4,4-Difluoro-5,7-Dimethyl-4-Bora-3,4-Diaza-3-Indacenepropionyl)Aminopentyl)Estradiol is a sophisticated chemical conjugate designed for advanced research and diagnostic applications. This compound combines the biological activity of estradiol with a BODIPY fluorophore, creating a powerful tool for fluorescence-based detection and imaging. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors. This high-purity reagent enables precise study and visualization of estrogen receptor-related pathways.

Application

• Fluorescent Probe Development: Serves as a critical component in creating sensitive probes for estrogen receptor (ER) detection and localization in cellular and tissue studies.
• Biomedical Research: Used in high-content screening (HCS) and fluorescence microscopy to investigate hormone signaling, receptor dynamics, and drug interactions.
• Diagnostic Assay Kits: Incorporated into in-vitro diagnostic (IVD) kits for the detection and quantification of estrogen-related biomarkers.
• Molecular Imaging: Enables targeted fluorescence imaging in preclinical research for oncology and endocrinology.
• Bioconjugation Standard: Acts as a reference standard in the synthesis and quality control of other fluorescently labeled steroid derivatives.
• Academic & Pharmaceutical R&D: Supports fundamental research in universities and drug discovery programs in pharmaceutical companies focused on hormone-dependent diseases.

Basic Information

Product Name	7-(5-(4,4-Difluoro-5,7-Dimethyl-4-Bora-3,4-Diaza-3-Indacenepropionyl)Aminopentyl)Estradiol
CAS No.	150393-31-0
Molecular Formula	C₃₈H₄₈BF₂N₃O₃
Molecular Weight	643.62 g/mol
Synonyms	Estradiol-BODIPY conjugate; BODIPY FL Estradiol; 7-(5-((4,4-Difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-propionyl)amino)pentyl)estradiol; BODIPY® FL C5-Estradiol; Fluorescent Estradiol Derivative; ERα Fluorescent Ligand; BODIPY-EDA-Estradiol; BODIPY FL E₂
EINECS	Contact for details

Quality Control

Our production of this high-value biochemical adheres to stringent quality protocols. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and fluorophore integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality system is designed to support research reproducibility and compliance with GLP (Good Laboratory Practice) standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider under an inert atmosphere to maintain optimal stability and fluorescence performance. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Orange to red solid or film
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Extinction Coefficient (ε)	~80,000 cm⁻¹M⁻¹ at ~504 nm
Fluorescence Emission	~511 nm
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.