Description

Methyl 5-Oxo-6,7,8,9-Tetrahydro-5H-Benzo[7]Annulene-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate with a complex fused-ring structure. This compound serves as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and inflammatory pathways. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in innovative drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, especially those with tricyclic or polycyclic frameworks.
• Organic Synthesis Building Block: Used in research-scale and pilot-scale reactions to construct novel chemical entities for biological screening.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to develop new therapeutic agents for neurological and anti-inflammatory applications.
• Process Chemistry Development: Serves as a standard or starting material for optimizing scalable and cost-effective synthetic routes for target molecules.
• Academic Research: Utilized in university and institutional labs for methodological studies in synthetic organic chemistry and heterocyclic compound synthesis.

Basic Information

Product Name	Methyl 5-Oxo-6,7,8,9-Tetrahydro-5H-Benzo[7]Annulene-2-Carboxylate
CAS No.	150192-89-5
Molecular Formula	C14H14O3
Molecular Weight	230.26 g/mol
Synonyms	Methyl 5-oxo-6,7,8,9-tetrahydro-5H-benzo[7]annulene-2-carboxylate; 5H-Benzo[7]annulene-2-carboxylic acid, 5-oxo-6,7,8,9-tetrahydro-, methyl ester; Methyl 5-oxo-5,6,7,8,9,10-hexahydrobenzo[8]annulene-2-carboxylate (alternative numbering); 2-(Methoxycarbonyl)-5-oxo-6,7,8,9-tetrahydro-5H-benzo[7]annulene
EINECS	Contact for details

Quality Control

Our production of Methyl 5-Oxo-6,7,8,9-Tetrahydro-5H-Benzo[7]Annulene-2-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All material is characterized and released against comprehensive specifications, which typically include identity confirmation by spectroscopic methods (IR, NMR), purity assessment by HPLC, and control of specific impurities. A Certificate of Analysis (COA) detailing all test results is provided with each shipment. We support cGMP compliance for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.