Description

Chloromethyl 3-((tert-Butoxycarbonyl)Amino)Propanoate CAS NO 150109-41-4 is a protected amino acid derivative, specifically a chloromethyl ester of a Boc-protected β-alanine analog. This compound is a critical building block in organic synthesis, valued for its dual functionality that enables selective peptide coupling and further molecular elaboration. It is primarily required by pharmaceutical R&D and fine chemical synthesis teams for constructing complex molecules, including active pharmaceutical ingredients (APIs) and peptide mimetics.

Application

• Pharmaceutical Intermediate: Key synthon in the synthesis of peptide-based drugs and protease inhibitors.
• Peptide Chemistry: Serves as a protected amino acid ester for solid-phase and solution-phase peptide synthesis (SPPS).
• Linker Molecule: Used in the preparation of antibody-drug conjugates (ADCs) and other bioconjugates due to its reactive chloromethyl group.
• Prodrug Synthesis: Employed in designing prodrugs where controlled release of an active moiety is required.
• Chemical Biology Probes: Building block for creating labeled peptides and activity-based probes for biochemical research.
• Custom Synthesis: Foundation for the custom manufacturing of complex organic molecules and novel chemical entities (NCEs).

Basic Information

Product Name	Chloromethyl 3-((tert-Butoxycarbonyl)Amino)Propanoate
CAS No.	150109-41-4
Molecular Formula	C9H16ClNO4
Molecular Weight	237.68 g/mol
Synonyms	3-[(tert-Butoxycarbonyl)amino]propanoic acid chloromethyl ester; Boc-β-Ala-OCH2Cl; N-Boc-β-alanine chloromethyl ester; (3-{[(tert-Butoxycarbonyl)amino]propanoic acid chloromethyl ester; Chloromethyl N-(tert-butoxycarbonyl)-β-alaninate; Boc-3-aminopropanoic acid chloromethyl ester; tert-Butyl N-(3-{[(chloromethoxy)carbonyl]oxy}propyl)carbamate (alternative form)
EINECS	Contact for details

Quality Control

Our Chloromethyl 3-((tert-Butoxycarbonyl)Amino)Propanoate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.