Description

n-Succinimidyl 4-Methyl-3-Iodobenzoate is a highly reactive, heterobifunctional cross-linking agent and a key intermediate in bioconjugation chemistry. It matters for its ability to efficiently introduce iodinated aromatic groups into biomolecules, enabling subsequent site-specific modifications via palladium-catalyzed cross-coupling reactions. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and antibody-drug conjugate (ADC) synthesis, where precise labeling and functionalization of proteins, peptides, and other bioactive molecules are required.

Application

• Bioconjugation Reagent: Primary use as an amine-reactive cross-linker for labeling proteins, antibodies, and peptides with an iodinated aromatic handle.
• Antibody-Drug Conjugate (ADC) Synthesis: Critical intermediate for constructing linker-payload complexes that can be further functionalized via click chemistry or Suzuki coupling.
• Proteomics & Biomarker Discovery: Used to tag and enrich biomolecules for mass spectrometry analysis and imaging.
• Radiopharmaceutical Precursor: Serves as a building block for synthesizing compounds where iodine-125 or iodine-131 can be incorporated for diagnostic or therapeutic applications.
• Surface Functionalization: Modification of nanoparticles, biosensors, and microarray surfaces to create bioactive interfaces.
• Chemical Biology Probes: Synthesis of activity-based probes and affinity labels for studying enzyme function and protein interactions.
• Polymer & Material Science: Incorporation into polymer backbones or dendrimers to create functional materials with specific reactivity.

Basic Information

Product Name	n-Succinimidyl 4-Methyl-3-Iodobenzoate
CAS No.	149879-60-7
Molecular Formula	C12H10INO4
Molecular Weight	359.12 g/mol
Synonyms	4-Methyl-3-iodobenzoic acid N-hydroxysuccinimide ester; 3-Iodo-4-methylbenzoic acid N-succinimidyl ester; N-Succinimidyl 3-iodo-4-methylbenzoate; NHS ester of 4-methyl-3-iodobenzoic acid; S-4-Methyl-3-Iodobenzoate; 4-Methyl-3-iodobenzoic acid, 2,5-dioxo-1-pyrrolidinyl ester; 149879-60-7; 3-Iodo-p-toluic acid N-succinimidyl ester
EINECS	Contact for details

Quality Control

Our n-Succinimidyl 4-Methyl-3-Iodobenzoate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, critical for sensitive bioconjugation applications. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.