Description

tert-Butyl 2-Azido-3-[(tert-Butoxycarbonyl)Amino]Propylcarbamate is a sophisticated bifunctional building block designed for advanced organic synthesis. This compound is valued for its dual-protected amine and azide functionalities, enabling precise and efficient construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and biotechnology sectors for applications such as peptide mimetics, bioconjugation, and the synthesis of novel drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring orthogonal protecting group strategies.
• Peptidomimetic Synthesis: Enables the incorporation of non-natural amino acid analogs into peptide chains to enhance stability and biological activity.
• Click Chemistry Reagent: The azide group facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC) for efficient bioconjugation and polymer modification.
• Linker Molecule for Drug Discovery: Used to create chemical linkers for antibody-drug conjugates (ADCs) and other targeted therapeutic platforms.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected amino acid derivative for the automated synthesis of complex peptides.
• Chemical Biology Probes: Employed in the development of activity-based probes and other tools for studying biological processes.

Basic Information

Product Name	tert-Butyl 2-Azido-3-[(tert-Butoxycarbonyl)Amino]Propylcarbamate
CAS No.	149876-85-7
Molecular Formula	C13H25N5O4
Molecular Weight	315.37 g/mol
Synonyms	Boc-Azidoalanine-OH; 2-Azido-3-[(tert-butoxycarbonyl)amino]propanoic acid tert-butyl ester; Nα-Boc-Nβ-Cbz-2,3-diaminopropionic acid tert-butyl ester (related); Boc-Dap(N3)-OtBu; (2R/S)-2-Azido-3-[(tert-butoxycarbonyl)amino]propanoic acid tert-butyl ester; tert-Butyl N-[(2-azido-1-ethoxycarbonyl)ethyl]carbamate; Azido-Boc-Dap-OtBu
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Azido-3-[(tert-Butoxycarbonyl)Amino]Propylcarbamate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.