Description

(S)-Boropro-(-)-Pinanediol-Hcl CAS NO 149716-73-4 is a high-purity, chiral boronic ester derivative used as a critical intermediate in advanced organic synthesis. This compound matters for its role in facilitating stereoselective carbon-carbon bond formation, particularly in Suzuki-Miyaura cross-coupling reactions, which are fundamental to modern pharmaceutical and agrochemical research. It is essential for R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality building blocks for creating complex, optically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting central nervous system disorders and other therapeutic areas requiring specific stereochemistry.
• Asymmetric Synthesis: Employed as a chiral auxiliary or reagent in asymmetric Suzuki-Miyaura cross-coupling reactions to construct stereogenic centers with high enantiomeric purity.
• Agrochemical Research: Used in the development of novel, enantiomerically pure pesticides and herbicides where biological activity is often stereospecific.
• Material Science: Serves as a precursor for creating chiral organic frameworks, polymers, or ligands for catalysis with specific optical properties.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) exploring new methodologies in organoboron chemistry and transition metal catalysis.
• Process Chemistry Development: Used for scaling up synthetic routes from laboratory to pilot plant and commercial production, where consistent quality is paramount.

Basic Information

Product Name	(S)-Boropro-(-)-Pinanediol-Hcl
CAS No.	149716-73-4
Molecular Formula	C₁₀H₁₈BClO₂
Molecular Weight	216.51 g/mol
Synonyms	(S)-(-)-Pinanediol (1R)-1-Chloro-3-borapentan-1-ol Hydrochloride; (S)-1-Chloro-3-borapentan-1-ol, (1R,2S,3R,5S)-(-)-Pinanediol Ester, Hydrochloride; (S)-Boropro Pinanediol Ester Hydrochloride; (S)-α-Chloroalkylboronic Acid Pinanediol Ester HCl; (S)-Boropro Pinacol Ester Hydrochloride (common misnomer); (S)-1-Chloro-3-boronopentan-1-ol Pinanediol Ester HCl; B-[(1S)-1-Chloro-3-hydroxypropyl]boronic Acid Pinanediol Ester Hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-Boropro-(-)-Pinanediol-Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as chiral purity (enantiomeric excess), chemical purity (by HPLC), and identity confirmation. Our quality commitment aligns with the standards expected in cGMP environments for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.